Adach B
Katedra i Klinika Neurologii Akademii Medycznej w Lublinie.
Ann Univ Mariae Curie Sklodowska Med. 1997;52:15-22.
The purpose of the study was to investigate the effect of polarizing mixture on the level of lactic and pyruvic acids in blood and cerebro-spinal fluid of patients with acute ischaemic stroke in the earliest phase of illness. The investigation was done in 20 patients with completed stroke and 16 with TIA, which were treated with polarizing mixture. The diminution of the level of lactic acid in blood and cerebro-spinal fluid near to normal values was found in patients with completed stroke after treatment with intravenous infusions of polarizing mixture, but the level of pyruvic acid in body fluids mentioned above was increased in unsteady way after this treatment. The concentrations of lactic and pyruvic acids in blood of patients with TIA after treatment with polarizing mixture in the first twenty-four hours of illness were insignificantly elevated in comparison with the control group. The significant diminution of the lactate/pyruvate ratio in cerebro-spinal fluid found in patients with completed stroke treated with polarizing mixture may be an index of reduction of lactic acid cedemogenic effect on the brain.
该研究的目的是调查极化液对急性缺血性中风患者疾病最早阶段血液和脑脊液中乳酸和丙酮酸水平的影响。对20例完全性中风患者和16例短暂性脑缺血发作（TIA）患者进行了调查，这些患者接受了极化液治疗。在接受静脉输注极化液治疗的完全性中风患者中，发现血液和脑脊液中乳酸水平降低至接近正常水平，但上述体液中丙酮酸水平在该治疗后呈不稳定升高。与对照组相比，TIA患者在疾病的头24小时接受极化液治疗后，血液中乳酸和丙酮酸的浓度略有升高。在接受极化液治疗的完全性中风患者中，脑脊液中乳酸/丙酮酸比值显著降低，这可能是乳酸对脑的致水肿作用降低的一个指标。
