Hörder M H, Pauli J K, Renovanz H D, Stiffler A
Int J Clin Pharmacol Biopharm. 1976 Oct;14(3):199-213.
Based on literature and on the results of this open clinical trial we conclude, that there is no connection between application of the above named group of drugs and the change in parameters of haemostasis function, which might lead to a manifest haemorrhagic diathesis. Within the period surveyed of 14 days no case of induced coagulopathy and particularly no thrombocytopenia was seen. The substances under consideration themselves did not exert any anticoagulatory effect nor did they potentiate or inhibit the effect of a concurrently given cumarin derivative.
基于文献以及这项开放性临床试验的结果，我们得出结论：上述药物组的应用与止血功能参数的变化之间没有关联，而这种变化可能导致明显的出血素质。在为期14天的观察期内，未出现诱发性凝血病病例，尤其未出现血小板减少症。所研究的物质本身没有任何抗凝作用，它们也不会增强或抑制同时给予的香豆素衍生物的作用。
