Nowak G, Glusa E, Herbst I, Schreiber S
Biomed Biochim Acta. 1985;44(3):475-84.
The secretolytic agent bromhexine and its active metabolite ambroxol prevent the collagen- and ADP-induced decrease in circulating blood platelets in rabbits, while they do not inhibit the aggregation induced by ADP, collagen or arachidonic acid of human and rabbit blood platelets in vitro. Bromhexine was found to exert beneficial effects on the disturbances of pulmonary function that might be caused by a reduced surfactant production observed during thrombin-induced disseminated intravascular coagulation in rats. The results suggest that bromhexine has a protective effect on the acute impairment of pulmonary function due to microthrombosis.
黏液溶解剂溴己新及其活性代谢物氨溴索可防止胶原蛋白和ADP诱导的家兔循环血小板减少，而在体外它们并不抑制人及家兔血小板由ADP、胶原蛋白或花生四烯酸诱导的聚集。发现溴己新对大鼠凝血酶诱导的弥散性血管内凝血期间观察到的表面活性剂产生减少可能引起的肺功能紊乱具有有益作用。结果表明，溴己新对微血栓形成所致的肺功能急性损害具有保护作用。
