Hiller E
MMW Munch Med Wochenschr. 1980 Aug 29;122(35):1184-90.
Side-effects of longterm therapy on the coagulation system become manifest either as hemorrhages or as an increased risk of thromboembolism. The most frequent drug-induced coagulation defect is thrombopathia. The most important drug-induced plasmatic coagulation disorders are caused by anti-coagulants and therefore predictable. In patients exposed to hemorrhage risk, non-steroidal antiphlogistics are not contraindicated since they entail inhibition of platelet aggregation and prolonged hemorrhage time. High doses of penicillin G and the semisynthetic penicillins can lead to hemorrhage in patients with renal insufficiency. Corticosteroids and contraceptives however tend to induce hypercoagulability.
长期治疗对凝血系统的副作用表现为出血或血栓栓塞风险增加。最常见的药物性凝血缺陷是血小板病。最重要的药物性血浆凝血障碍是由抗凝剂引起的，因此是可预测的。对于有出血风险的患者，非甾体抗炎药并非禁忌，因为它们会抑制血小板聚集并延长出血时间。大剂量青霉素G和半合成青霉素可导致肾功能不全患者出血。然而，皮质类固醇和避孕药往往会导致血液高凝状态。
