Folsom A R, Jensen M D, Jacobs D R, Hilner J E, Tsai A W, Schreiner P J
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA.
Obes Res. 1999 Jan;7(1):1-8. doi: 10.1002/j.1550-8528.1999.tb00384.x.
There is considerable interest in how to prevent weight gain in adulthood. Leptin, a peptide hormone expressed in adipose tissue, is believed to signal the central nervous system about the level of body fat stores, and thereby may control appetite. Little information exists on whether the serum leptin concentration influences long-term weight changes in the free-living population.
From an ongoing cohort study of young African American and white adults, we selected a sample of participants (n=492), stratified on sex, race, and weight changes over 8 years. Serum leptin was measured on stored specimens using a radioimmunoassay. Weight change was modeled in relation to baseline leptin concentrations.
Cross-sectionally, leptin concentration was associated positively with body mass index, negatively with physical activity level, and was higher in women than men. These variables explained 72% of the variance in serum leptin. Over the 8 years, the sample gained an average of 7.8 kg (standard deviation = 10.8). There was no evidence that 8-year weight change was associated with initial leptin concentration: 8-year weight change was only 0.5 kg less (95% confidence interval =-1.8 to 0.8, p = 0.47) per each 10 ng/ mL increment (approximately one standard deviation) of baseline leptin. In contrast, leptin change correlated highly (r=0.62) with weight change.
Our data corroborate evidence that adiposity determines leptin levels but do not support the hypothesis that leptin deficiency plays an important role in obesity in the general population.
如何预防成年期体重增加备受关注。瘦素是一种在脂肪组织中表达的肽类激素，被认为可向中枢神经系统传递身体脂肪储存水平的信号，从而可能控制食欲。关于血清瘦素浓度是否会影响自由生活人群的长期体重变化，目前所知甚少。
从一项正在进行的针对年轻非裔美国人和白人成年人的队列研究中，我们选取了一组参与者样本（n = 492），并根据性别、种族和8年期间的体重变化进行分层。使用放射免疫分析法对储存样本中的血清瘦素进行测量。以基线瘦素浓度为自变量建立体重变化模型。
横断面分析显示，瘦素浓度与体重指数呈正相关，与身体活动水平呈负相关，且女性高于男性。这些变量解释了血清瘦素变异的72%。在这8年中，样本平均增重7.8千克（标准差 = 10.8）。没有证据表明8年的体重变化与初始瘦素浓度有关：每增加10纳克/毫升（约一个标准差）的基线瘦素，8年体重变化仅减少0.5千克（95%置信区间 = -1.8至0.8，p = 0.47）。相反，瘦素变化与体重变化高度相关（r = 0.62）。
我们的数据证实了肥胖决定瘦素水平的证据，但不支持瘦素缺乏在一般人群肥胖中起重要作用这一假设。
