Nicklas B J, Toth M J, Goldberg A P, Poehlman E T
Department of Medicine, University of Maryland School of Medicine, Baltimore, USA.
J Clin Endocrinol Metab. 1997 Jan;82(1):315-7. doi: 10.1210/jcem.82.1.3659.
Leptin may play an important role in the regulation of body weight by influencing energy intake and expenditure. Differences in body composition, resting energy expenditure (REE), and physical activity between African-American and Caucasian women could be reflective of racial differences in plasma leptin concentrations. Thus, we examined racial differences in leptin levels and the relationships of leptin to body composition and resting metabolism in obese postmenopausal African-American (n = 28) and Caucasian (n = 29) women matched for level of body fat. African-American and Caucasian women were similar in age (64.1 +/- 1.3 vs. 63.2 +/- 1.0 yr), body weight (84.7 +/- 3.3 vs. 80.4 +/- 1.3 kg), adipose tissue mass (39.7 +/- 2.8 vs. 38.0 +/- 1.0 kg), waist to hip ratio (0.81 +/- 0.02 vs. 0.81 +/- 0.01), and maximal aerobic capacity (1.5 +/- 0.05 vs. 1.6 +/- 0.05 L/min). African-American women had greater lean tissue mass than Caucasian women (41.8 +/- 1.1 vs. 39.3 +/- 0.6 kg; P = 0.05). The leptin concentration was 20% lower in African-American than Caucasian women (36.0 +/- 4.8 vs. 45.8 +/- 3.5; P < 0.05), whereas REE values were similar. Leptin correlated strongly with percent body fat in African-American (r = 0.71; P < 0.0001) and Caucasian women (r = 0.61; P < 0.001) and with REE in African-American (r = 0.58; P < 0.001), but not Caucasian, women (r = 0.08). These findings suggest racial differences in plasma leptin levels and in leptin's role in the regulation of REE, which may play a role in the greater incidence of obesity in the African-American compared to the Caucasian population.
瘦素可能通过影响能量摄入和消耗在体重调节中发挥重要作用。非裔美国女性和白人女性在身体成分、静息能量消耗（REE）和体力活动方面的差异可能反映了血浆瘦素浓度的种族差异。因此，我们研究了肥胖绝经后非裔美国女性（n = 28）和白人女性（n = 29）在瘦素水平上的种族差异，以及瘦素与身体成分和静息代谢的关系，这些女性的体脂水平相匹配。非裔美国女性和白人女性在年龄（64.1±1.3岁对63.2±1.0岁）、体重（84.7±3.3千克对80.4±1.3千克）、脂肪组织质量（39.7±2.8千克对38.0±1.0千克）、腰臀比（0.81±0.02对0.81±0.01）和最大有氧能力（1.5±0.05升/分钟对1.6±0.05升/分钟）方面相似。非裔美国女性的瘦组织质量高于白人女性（41.8±1.1千克对39.3±0.6千克；P = 0.05）。非裔美国女性的瘦素浓度比白人女性低20%（36.0±4.8对45.8±3.5；P < 0.05），而REE值相似。瘦素与非裔美国女性（r = 0.71；P < 0.0001）和白人女性（r = 0.61；P < 0.001）的体脂百分比以及非裔美国女性（r = 0.58；P < 0.001）的REE密切相关，但与白人女性（r = 0.08）的REE无关。这些发现表明血浆瘦素水平以及瘦素在调节REE中的作用存在种族差异，这可能在非裔美国人肥胖发生率高于白人人群中起作用。
