在健康人体受试者中使用单胺囊泡转运体抑制剂11C-DTBZ的重复性研究。
Reproducibility studies with 11C-DTBZ, a monoamine vesicular transporter inhibitor in healthy human subjects.
作者信息
Chan G L, Holden J E, Stoessl A J, Samii A, Doudet D J, Dobko T, Morrison K S, Adam M, Schulzer M, Calne D B, Ruth T J
机构信息
TRIUMF and Neurodegenerative Disorders Center, University of British Columbia, Vancouver, Canada.
出版信息
J Nucl Med. 1999 Feb;40(2):283-9.
UNLABELLED
The reproducibility of (+/-)-alpha-[11C] dihydrotetrabenazine (DTBZ) measures in PET was studied in 10 healthy human subjects, aged 22-76 y.
METHODS
The scan-to-scan variation of several measures used in PET data analysis was determined, including the radioactivity ratio (target-to-reference), plasma-input Logan total distribution volume (DV), plasma-input Logan Bmax/Kd and tissue-input Logan Bmax/Kd values.
RESULTS
The radioactivity ratios, plasma-input Bmax/Kd and tissue-input Bmax/Kd all have higher reliability than plasma-input total DV values. In addition, measures using the occipital cortex as the reference region have higher reliability than the same measures using the cerebellum as the reference region.
CONCLUSION
Our results show that DTBZ is a reliable PET tracer that provides reproducible in vivo measurement of striatal vesicular monoamine transporter density. In the selection of reference regions for DTBZ PET data analysis, caution must be exercised in circumstances when DTBZ binding in the occipital cortex or the cerebellum may be altered.
未标注
在10名年龄为22 - 76岁的健康人类受试者中研究了PET中（±）-α-[¹¹C]二氢四苯嗪（DTBZ）测量的可重复性。
方法
确定了PET数据分析中使用的几种测量方法的扫描间变化，包括放射性比值（靶区与参考区）、血浆输入洛根总分布容积（DV）、血浆输入洛根Bmax/Kd以及组织输入洛根Bmax/Kd值。
结果
放射性比值、血浆输入Bmax/Kd和组织输入Bmax/Kd的可靠性均高于血浆输入总DV值。此外，以枕叶皮质作为参考区域的测量方法比以小脑作为参考区域的相同测量方法具有更高的可靠性。
结论
我们的结果表明，DTBZ是一种可靠的PET示踪剂，可提供纹状体囊泡单胺转运体密度的可重复体内测量。在为DTBZ PET数据分析选择参考区域时，当枕叶皮质或小脑中的DTBZ结合可能改变时，必须谨慎行事。
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