Chan G L, Holden J E, Stoessl A J, Doudet D J, Wang Y, Dobko T, Morrison K S, Huser J M, English C, Legg B, Schulzer M, Calne D B, Ruth T J
TRIUMF and Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada.
J Nucl Med. 1998 May;39(5):792-7.
The reproducibility of [11C]SCH 23390 in PET was studied in 10 normal human subjects.
The scan-to-scan variation of several measures used in PET data analysis, including the radioactivity ratio, plasma-input Logan total distribution volume (DV), plasma-input Logan DV ratio (DVR) and tissue-input Logan Bmax/Kd values, was determined.
There were significant correlations among the radioactivity ratio, plasma-input DVR and tissue-input Bmax/Kd. With the cerebellum as the reference region, these three measures also had high reliability (86%-95%), high between-subject s.d. (7.7%-11.3%) and small within-subject s.d. (2.3%-3.6%), indicating that they are comparable and useful measures for the assessment of dopamine D1 receptor binding.
The radioactivity ratio and the tissue-input Bmax/Kd may be preferred methods for the evaluation of dopamine D1 receptor binding because these two methods do not require arterial blood sampling and metabolite analysis. Our results show that cerebellum is a reliable reference region for SCH 23390. When the Logan plasma-input function method is used in data analysis for SCH 23390, DVRs rather than total DV values should be used because of the poor reliability of the DV values and their lack of correlation with other measures. Carbon-11-SCH 23390 is thus a reliable and reproducible ligand for the study of dopamine D1 receptor binding by PET.
在10名正常人类受试者中研究了[11C]SCH 23390在正电子发射断层扫描（PET）中的可重复性。
确定了PET数据分析中使用的几种测量方法的逐次扫描变化，包括放射性比值、血浆输入洛根总分布容积（DV）、血浆输入洛根DV比值（DVR）和组织输入洛根Bmax/Kd值。
放射性比值、血浆输入DVR和组织输入Bmax/Kd之间存在显著相关性。以小脑作为参考区域，这三种测量方法也具有高可靠性（86%-95%）、高受试者间标准差（7.7%-11.3%）和低受试者内标准差（2.3%-3.6%），表明它们是用于评估多巴胺D1受体结合的可比且有用的测量方法。
放射性比值和组织输入Bmax/Kd可能是评估多巴胺D1受体结合的首选方法，因为这两种方法不需要动脉血采样和代谢物分析。我们的结果表明小脑是SCH 23390的可靠参考区域。当在SCH 23390的数据分析中使用洛根血浆输入函数法时，由于DV值的可靠性差及其与其他测量方法缺乏相关性，应使用DVR而不是总DV值。因此，碳-11-SCH 23390是一种用于通过PET研究多巴胺D1受体结合的可靠且可重复的配体。
