Elgart G W, Hanly A, Busso M, Spencer J M
University of Miami Department of Dermatology and Cutaneous Surgery, Florida, USA.
J Am Acad Dermatol. 1999 Feb;40(2 Pt 2):315-7. doi: 10.1016/s0190-9622(99)70474-3.
Bednar tumor is a rare pigmented variant of dermatofibrosarcoma protuberans (DFSP). Because of its rarity, information is lacking regarding the optimal therapy and potential utility of immunohistochemistry in diagnosis. We report a case of Bednar tumor in which the diagnosis was aided by immunohistochemistry for CD34, an antigen known to be expressed in DFSP but not previously reported in Bednar tumor. Our case was also striking because it represents the first reported appearance of a Bednar tumor at a site of prior immunization, a phenomenon previously noted in some cases of DFSP. The patient was treated effectively with Mohs surgery and is without recurrence at 9 months.
贝德纳瘤是隆突性皮肤纤维肉瘤（DFSP）的一种罕见色素沉着变体。由于其罕见性，关于最佳治疗方法以及免疫组织化学在诊断中的潜在作用的信息尚缺。我们报告一例贝德纳瘤，其诊断借助了针对CD34的免疫组织化学检测，CD34是一种已知在DFSP中表达但此前未报道在贝德纳瘤中表达的抗原。我们的病例也很引人注目，因为它代表了首次报道的贝德纳瘤出现在先前免疫接种部位的情况，这种现象此前在一些DFSP病例中已有记录。该患者接受莫氏手术治疗效果良好，9个月时无复发。
