Haycox C L, Odland P B, Olbricht S M, Piepkorn M
Division of Dermatology, University of Washington, Seattle 98195-6524, USA.
J Am Acad Dermatol. 1997 Sep;37(3 Pt 1):438-44. doi: 10.1016/s0190-9622(97)70146-4.
Dermatofibrosarcoma protuberans (DFSP) is a rare, clinically challenging, soft tissue tumor. The main histologic differential of DFSP is usually a dermatofibroma. In 1990, the first report appeared demonstrating that cells of DFSP express the human progenitor antigen CD34 on their surface. Since then, there have been increasing reports of the usefulness of immunohistochemical staining with CD34 to differentiate DFSP from dermatofibroma and other soft tissue tumors. This literature is reviewed with special emphasis on the insights studies have provided into the histogenesis of DFSP. The literature demonstrating the practical applications of CD34 staining in the diagnosis and treatment of DFSP is also discussed.
隆突性皮肤纤维肉瘤（DFSP）是一种罕见的、具有临床挑战性的软组织肿瘤。DFSP主要的组织学鉴别诊断通常是皮肤纤维瘤。1990年，首次有报告表明DFSP细胞在其表面表达人祖细胞抗原CD34。从那时起，越来越多的报告指出用CD34进行免疫组化染色有助于将DFSP与皮肤纤维瘤及其他软组织肿瘤区分开来。本文对该文献进行综述，特别强调了研究所提供的关于DFSP组织发生的见解。还讨论了证明CD34染色在DFSP诊断和治疗中的实际应用的文献。
