Lee E, Surh Y J
College of Pharmacy, Seoul National University, South Korea.
Cancer Lett. 1998 Dec 25;134(2):163-8. doi: 10.1016/s0304-3835(98)00253-5.
[6]-Gingerol, a major pungent ingredient found in the rhizome of ginger, has been reported to possess a strong antiinflammatory activity, which is considered to be closely associated with its cancer chemopreventive potential. [6]-Paradol, another pungent phenolic substance found in ginger and other Zingiberaceae plants, also has a vanilloid structure found in other chemopreventive phytochemicals including curcumin. In the present study, [6]-gingerol and [6]-paradol were found to exert inhibitory effects on the viability and DNA synthesis of human promyelocytic leukemia (HL-60) cells. The cytotoxic and antiproliferative effects of both compounds were associated with apoptotic cell death. The above results suggest that [6]-gingerol and [6]-paradol possess potential cytotoxic/cytostatic activities.
姜辣素是生姜根茎中的一种主要辛辣成分，据报道具有很强的抗炎活性，这被认为与其癌症化学预防潜力密切相关。 paradol是在生姜和其他姜科植物中发现的另一种辛辣酚类物质，它也具有在包括姜黄素在内的其他化学预防植物化学物质中发现的香草酸结构。在本研究中，发现姜辣素和paradol对人早幼粒细胞白血病（HL-60）细胞的活力和DNA合成具有抑制作用。两种化合物的细胞毒性和抗增殖作用都与凋亡性细胞死亡有关。上述结果表明，姜辣素和paradol具有潜在的细胞毒性/细胞生长抑制活性。
