Takenaka H, Kishimoto S, Shibagaki R, Nagata M, Noda Y, Yasuno H
Department of Dermatology, Kyoto Prefectural University of Medicine, Japan.
Br J Dermatol. 1998 Oct;139(4):726-9.
We report a 59-year-old woman who exhibited a recurrent malignant proliferating trichilemmal tumour on the scalp for 1 5 years. The tumour was recalcitrant to conventional treatments such as chemotherapy, radiation or hyperthermia and we performed intratumoral ethanol injection as an alternative means of reducing tumour mass and obtaining haemostasis. Biopsy specimens obtained after the ethanol injection revealed oedema, haemorrhage in the dermis and degeneration of the tumour cells, showing vacuolization with pyknotic nuclei. For cases of recurrent skin tumours and for patients in poor clinical condition, intratumoral ethanol injection is likely to be a therapeutic alternative to surgery or other conventional treatments.
我们报告了一名59岁女性，其头皮复发性恶性增生性外毛根鞘瘤已存在15年。该肿瘤对化疗、放疗或热疗等传统治疗方法均无效，我们采用瘤内乙醇注射作为减少肿瘤体积和止血的替代方法。乙醇注射后获取的活检标本显示有水肿、真皮内出血以及肿瘤细胞变性，表现为核固缩的空泡化。对于复发性皮肤肿瘤病例以及临床状况较差的患者，瘤内乙醇注射可能是手术或其他传统治疗的一种替代治疗方法。
