Ichthyosis in two dogs.

Ichthyosis in 2 dogs was characterized by extreme hyperkeratosis on all or part of the skin and by extreme thickening of the digital and metapodial pads. The skin disorder closely resembled human lamellar ichthyosis, in which the histologic features include a thickened granular layer, mitotic figures, and dense collections of coarse keratohyaline granules. The disease was believed to be inherited, probably autosomal recessive, inasmuch as none of the parents was affected. Treatment of 1 dog with 5% lactic acid in hydrophilic ointment reduced the hyperkeratosis and decreased the shedding of scales.