Bronge L, Fernaeus S E, Blomberg M, Ingelson M, Lannfelt L, Isberg B, Wahlund L O
Radiology, Division of Geriatric Medicine, Huddinge University Hospital, Huddinge, Sweden.
Dement Geriatr Cogn Disord. 1999 Mar-Apr;10(2):89-96. doi: 10.1159/000017107.
To analyse the influence of apolipoprotein E (APOE) genotype on the extent of white matter lesions (WMLs) in Alzheimer's disease (AD), we examined 60 AD patients with magnetic resonance imaging. The WMLs were rated visually in different brain regions. The patients with the APOE genotype sigma4/4 had more extensive WMLs in the deep white matter than patients with genotypes sigma3/3 and sigma3/4. There was a correlation with age for WMLs in the deep white matter in patients with the APOE sigma3/3 genotype. In patients carrying at least one sigma4 allele, the WMLs showed no age correlation. The results could imply that in APOE allele sigma4 carriers, the WMLs represent a pathological process related to the aetiology of the disease.
为分析载脂蛋白E（APOE）基因型对阿尔茨海默病（AD）患者白质病变（WMLs）程度的影响，我们对60例AD患者进行了磁共振成像检查。在不同脑区对WMLs进行视觉评分。APOE基因型为ε4/4的患者深部白质中的WMLs比基因型为ε3/3和ε3/4的患者更广泛。APOE基因型为ε3/3的患者深部白质中的WMLs与年龄相关。在携带至少一个ε4等位基因的患者中，WMLs与年龄无相关性。结果可能意味着，在APOE ε4等位基因携带者中，WMLs代表了与疾病病因相关的病理过程。
