University Center for Geriatric Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
PLoS One. 2011;6(11):e27415. doi: 10.1371/journal.pone.0027415. Epub 2011 Nov 14.
APOE genotype is associated with the risk of Alzheimer's disease. In the present study, we investigated whether APOE genotype was associated with cognitive function in predominantly middle-aged persons. In a population-based cohort of 4,135 persons aged 35 to 82 years (mean age (SD), 55 (12) years), cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points). APOE genotype (rs429358 and rs7412) was determined by polymerase chain reaction. The mean RFFT score (SD) of the total cohort was 69 (26) points. Unadjusted, the mean RFFT score in homozygous APOE ε4 carriers was 4.66 points lower than in noncarriers (95% confidence interval, -9.84 to 0.51; p = 0.08). After adjustment for age and other risk factors, the mean RFFT score in homozygous APOE ε4 carriers was 5.24 points lower than in noncarriers (95% confidence interval, -9.41 to -1.07; p = 0.01). The difference in RFFT score was not dependent on age. There was no difference in RFFT score between heterozygous APOE ε4 carriers and noncarriers. The results indicated that homozygous APOE ε4 carriers aged 35 years or older had worse cognitive function than heterozygous carriers and noncarriers.
载脂蛋白 E 基因型与阿尔茨海默病的风险相关。本研究旨在探究载脂蛋白 E 基因型是否与主要为中年人群的认知功能相关。在一个基于人群的队列中，纳入了 4135 名年龄在 35 至 82 岁（平均年龄（标准差），55（12）岁）的人群，使用瑞夫图形流畅测验（RFFT；最差得分为 0 分，最好得分为 175 分）来测量认知功能。通过聚合酶链反应确定载脂蛋白 E 基因型（rs429358 和 rs7412）。整个队列的平均 RFFT 评分（标准差）为 69（26）分。未经校正时，纯合子 APOE ε4 携带者的平均 RFFT 评分比非携带者低 4.66 分（95%置信区间，-9.84 至 0.51；p=0.08）。校正年龄和其他危险因素后，纯合子 APOE ε4 携带者的平均 RFFT 评分比非携带者低 5.24 分（95%置信区间，-9.41 至 -1.07；p=0.01）。RFFT 评分的差异与年龄无关。杂合子 APOE ε4 携带者与非携带者的 RFFT 评分无差异。结果表明，年龄在 35 岁及以上的纯合子 APOE ε4 携带者的认知功能比杂合子携带者和非携带者差。
