Marzano A V, Kolesnikova L V, Gasparini G, Alessi E
Istituto di Scienze Dermatologiche, Università degli Studi di Milano, IRCCS Ospedale Maggiore di Milano, Italia.
Dermatology. 1999;198(1):90-2. doi: 10.1159/000018074.
Dystrophic calcinosis cutis is known to be associated with various connective tissue disorders but to the best of our knowledge has never been reported in subacute cutaneous lupus erythematosus (SCLE), a distinctive cutaneous subset in the spectrum of lupus erythematosus. It occurs without calcium and phosphorus metabolic abnormalities and may be localized or generalized. We report a patient with SCLE who developed calcinosis cutis and had normal serum calcium and phosphorus levels and, interestingly, a normal concentration of blood ionized calcium. This latter, which represents the active form in the total amount of blood calcium, is a parameter only rarely assessed in patients with dystrophic calcinosis cutis. Thus, other pathogenic factors should be investigated to clarify the pathophysiology of the dystrophic type of calcification.
已知营养不良性皮肤钙化症与多种结缔组织疾病相关，但据我们所知，在亚急性皮肤型红斑狼疮（SCLE）中从未有过报道，SCLE是红斑狼疮谱系中的一种独特皮肤亚型。它在无钙磷代谢异常的情况下发生，可为局限性或全身性。我们报告了1例SCLE患者，该患者出现了皮肤钙化症，血清钙和磷水平正常，有趣的是，血离子钙浓度也正常。血离子钙代表血钙总量中的活性形式，是营养不良性皮肤钙化症患者很少评估的一个参数。因此，应研究其他致病因素以阐明营养不良型钙化的病理生理学。
