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特发性钙质沉着症相关系统性红斑狼疮 1 例报告

Dystrophic calcinosis cutis associated with systemic lupus erythematosus: a case report.

机构信息

Department of Clinical Immunology, Centro Hospitalar Universitário do Porto, Porto, Portugal.

Department of Internal Medicine, Centro Hospitalar Tondela Viseu, Viseu, Portugal.

出版信息

Pan Afr Med J. 2021 Dec 22;40:258. doi: 10.11604/pamj.2021.40.258.28215. eCollection 2021.

Abstract

Calcinosis cutis is a rare and potentially disabling condition characterized by calcium deposition in soft tissues. When associated with autoimmune connective tissue diseases, calcinosis cutis is classified as Dystrophic Calcinosis Cutis (DCC), being its occurrence in systemic lupus erythematosus (SLE) patients fairly uncommon. We report a case of DCC in a 49 years old woman with eleven years evolution SLE that presented with a two years history of multiple painful skin lesions, some of them ulcerated and exhibiting a chalky white-yellow floor, in both hands, forearms, thighs, buttocks, abdomen and left breast. The pelvic X-ray showed soft tissue calcifications and the skin biopsy confirmed the diagnosis of DCC. The patient was treated with diltiazem 240mg/day and a significant regression of the lesions and associated pain was observed. Dystrophic calcinosis cutis is often a painful and disrupting condition in which timely diagnosis and treatment may be quite challenging.

摘要

皮肤钙化病是一种罕见且可能致残的疾病,其特征是钙在软组织中沉积。当与自身免疫性结缔组织疾病相关时,皮肤钙化病被分类为营养不良性皮肤钙化病(DCC),在系统性红斑狼疮(SLE)患者中较为罕见。我们报告了一例 49 岁女性的 DCC,该患者患有 11 年的 SLE,表现为双手、前臂、大腿、臀部、腹部和左侧乳房出现多个疼痛性皮肤病变,其中一些病变已经溃疡,呈现出白垩黄色的底部。骨盆 X 射线显示软组织钙化,皮肤活检证实了 DCC 的诊断。患者接受了地尔硫䓬 240mg/天的治疗,皮肤病变和相关疼痛显著消退。营养不良性皮肤钙化病常导致疼痛和功能障碍,及时诊断和治疗可能颇具挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c167/8856974/59cf7c3f4255/PAMJ-40-258-g001.jpg

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