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人肾神经节苷脂

Gangliosides of human kidney.

作者信息

Rauvala H

出版信息

J Biol Chem. 1976 Dec 10;251(23):7517-20.

PMID:1002698
Abstract

Five gangliosides isolated from human kidney have been characterized. The two main fractions were shown to be typical extraneural gangliosides in having lactose as their neutral carbohydrate moiety. Their structures were identified as: AcNeu(alpha2-3)Gal(beta1-4)Glc(beta1-1)Cer and AcNeu(alpha2-8)AcNeu(alpha2-3)Gal(beta1-4)Glc(beta1-1)Cer. The two main hexosamine-containing gangliosides are structurally related to human blood group substances of glycosphingolipid nature. The following structures are postulated: AcNeu(alpha2-3)Gal(beta1-4)GlcNAc(beta1-3)Gal(beta1-4)Glc(beta1-1)Cer and AcNeu(alpha2-3)Gal(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)Gal(beta1-4)Glc(beta1-1)Cer. The third hexosamine-containing ganglioside belongs to a different series of glycolipids and was shown to have the structure of a major ganglioside of human brain: AcNeu(alpha2-3)Gal(beta1-3)GalNAc(beta1-4)[AcNeu(alpha2-3)]Gal(beta1-4)Glc(beta1-1)Cer. The fatty acid structure of different gangliosides was shown to resemble that of neutral glycolipids of human kidney with the nonhydroxy acids C16:0, C22:0, and C24:0 as major components.

摘要

已对从人肾中分离出的五种神经节苷脂进行了表征。两个主要组分被证明是典型的非神经节苷脂，其中性碳水化合物部分为乳糖。它们的结构被鉴定为：AcNeu(α2-3)Gal(β1-4)Glc(β1-1)Cer和AcNeu(α2-8)AcNeu(α2-3)Gal(β1-4)Glc(β1-1)Cer。两种主要的含己糖胺神经节苷脂在结构上与人血型物质中的糖鞘脂相关。推测其结构如下：AcNeu(α2-3)Gal(β1-4)GlcNAc(β1-3)Gal(β1-4)Glc(β1-1)Cer和AcNeu(α2-3)Gal(β1-4)[Fuc(α1-3)]GlcNAc(β1-3)Gal(β1-4)Glc(β1-1)Cer。第三种含己糖胺神经节苷脂属于不同系列的糖脂，被证明具有人脑中主要神经节苷脂的结构：AcNeu(α2-3)Gal(β1-3)GalNAc(β1-4)[AcNeu(α2-3)]Gal(β1-4)Glc(β1-1)Cer。不同神经节苷脂的脂肪酸结构显示与人肾中性糖脂的脂肪酸结构相似，主要成分是不含羟基的酸C16:0、C22:0和C24:0。

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