Holemans K, Gerber R T, Meurrens K, De Clerck F, Poston L, Van Assche F A
Department of Obstetrics and Gynaecology, Katholieke Universiteit Leuven, Belgium.
Diabetologia. 1999 Jan;42(1):81-9. doi: 10.1007/s001250051117.
Severe diabetes in pregnant rats produces persistent metabolic consequences in adult offspring. This study investigated whether diabetes in pregnant rats could also lead to cardiovascular abnormalities in the adult offspring. Blood pressure, heart rate and in vitro vascular reactivity of small arteries were evaluated in female adult offspring of control rats and of rats rendered diabetic with streptozotocin. Rise in blood pressures were similar in both groups of offspring but heart rate was lower in the diabetic offspring (p < 0.05). The rise in blood pressure associated with infusion of a nitric oxide synthase inhibitor was similar in both groups, but the associated decrease in heart rate was more pronounced in diabetic offspring (p < 0.01). Small mesenteric arteries from this group showed enhanced sensitivity to noradrenaline (p < 0.05) and abnormal endothelium-dependent relaxation to acetylcholine (p < 0.01) and bradykinin (p < 0.05). Reduction in acetylcholine induced relaxation, reflected reduced synthesis of nitric oxide or a cyclooxygenase product and was not attributable to an endothelium-derived hyperpolarizing factor. Sensitivity to exogenous nitric oxide was normal. A subgroup of pups born to diabetic dams were suckled by control maternal dams and a subgroup of those born to controls by diabetic dams. Suckling was an important determinant of impaired growth; offspring of diabetic rats suckled by their own mother and those of control rats by diabetic dams showed impaired growth rates whereas growth of offspring of diabetic rats suckled by control dams paralleled those of control rats suckled by their own mother.
妊娠大鼠的严重糖尿病会在成年子代中产生持续的代谢后果。本研究调查了妊娠大鼠的糖尿病是否也会导致成年子代出现心血管异常。对对照大鼠以及用链脲佐菌素诱导糖尿病的大鼠的成年雌性子代，评估其血压、心率和小动脉的体外血管反应性。两组子代的血压升高情况相似，但糖尿病子代的心率较低（p<0.05）。两组中，与输注一氧化氮合酶抑制剂相关的血压升高相似，但糖尿病子代中与之相关的心率下降更为明显（p<0.01）。该组的小肠系膜小动脉对去甲肾上腺素的敏感性增强（p<0.05），对乙酰胆碱（p<0.01）和缓激肽（p<0.05）的内皮依赖性舒张异常。乙酰胆碱诱导的舒张功能降低，反映出一氧化氮或环氧化酶产物的合成减少，且不归因于内皮源性超极化因子。对外源性一氧化氮的敏感性正常。糖尿病母鼠所生幼崽的一个亚组由对照母鼠哺乳，对照母鼠所生幼崽的一个亚组由糖尿病母鼠哺乳。哺乳是生长受损的一个重要决定因素；由自己母亲哺乳的糖尿病大鼠子代以及由糖尿病母鼠哺乳的对照大鼠子代生长速率受损，而由对照母鼠哺乳的糖尿病大鼠子代的生长与由自己母亲哺乳的对照大鼠子代相似。
