Zhang Ze, Zhang Yumeng, Huang Shuai, Li Min, Li Lingjun, Qi Linglu, He Yun, Xu Zhice, Tang Jiaqi
Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Ultrasound Department, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Front Endocrinol (Lausanne). 2025 May 16;16:1474643. doi: 10.3389/fendo.2025.1474643. eCollection 2025.
Gestational diabetes mellitus (GDM) is one of the most common endocrine-related complications during pregnancy, and its prevalence has increased over the past three decades. GDM adversely affects the maternal cardiovascular system, umbilical-placental blood perfusion, and fetal blood flow. We conducted a comprehensive literature search and systematically evaluated and synthesized cardiovascular changes in the mothers, umbilical-placental circulation, and the progeny following exposure to GDM. Multiple pathophysiological mechanisms underlying cardiovascular alteration were investigated, including endothelial dysfunction, insulin resistance, oxidative stress, ion channel abnormalities, inflammation, angiogenic imbalance, and epigenetic modifications. These findings provide valuable insights for developing early intervention strategies and therapeutic approaches to mitigating cardiovascular risks in both mothers and offspring following GDM exposure.
妊娠期糖尿病（GDM）是孕期最常见的内分泌相关并发症之一，在过去三十年中其患病率有所上升。GDM会对母体心血管系统、脐胎盘血液灌注和胎儿血流产生不利影响。我们进行了全面的文献检索，并系统地评估和综合了母亲、脐胎盘循环以及子代在暴露于GDM后的心血管变化。研究了心血管改变背后的多种病理生理机制，包括内皮功能障碍、胰岛素抵抗、氧化应激、离子通道异常、炎症、血管生成失衡和表观遗传修饰。这些发现为制定早期干预策略和治疗方法提供了有价值的见解，以减轻GDM暴露后母亲和子代的心血管风险。
