Lindblad P, Chow W H, Chan J, Bergström A, Wolk A, Gridley G, McLaughlin J K, Nyrén O, Adami H O
Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden.
Diabetologia. 1999 Jan;42(1):107-12. doi: 10.1007/s001250051122.
To investigate the relation between diabetes mellitus and the risk of renal cell cancer we carried out a population-based retrospective cohort study. Patients identified in the Swedish Inpatient Register who were discharged from hospitals with a diagnosis of diabetes mellitus between 1965 and 1983 formed a cohort of 153852 patients (80005 women and 73847 men). The cohort members were followed up to 1989 by record linkage to three nation-wide registries. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) were computed using age-specific sex-specific and period-specific incidence and mortality rates derived from the entire Swedish population. After exclusion of the first year of observation, a total of 267 incidences of renal cell cancer (ICD-7:180.0) occurred in diabetic patients compared with the 182.4 that had been expected. Increased risks were observed in both women (SIR = 1.7, 95% confidence interval, CI = 1.4-2.0) and men (SIR = 1.3; 95 % CI = 1.1-1.6) throughout the duration of follow-up (1-25 years). A higher risk was seen for kidney cancer (ICD-7:180) mortality (SMR = 1.9; 95% CI = 1.7-2.2, women; SMR 1.7, 95% CI = 1.4-1.9, men). In comparison with the general population, patients with diabetes mellitus have an increased risk of renal cell cancer.
为了研究糖尿病与肾细胞癌风险之间的关系，我们开展了一项基于人群的回顾性队列研究。在瑞典住院患者登记册中识别出的、于1965年至1983年间因糖尿病诊断而从医院出院的患者组成了一个队列，共153852名患者（80005名女性和73847名男性）。通过与三个全国性登记册进行记录链接，对队列成员进行随访至1989年。使用从整个瑞典人口得出的年龄、性别和时期特异性发病率和死亡率，计算标准化发病率（SIR）和标准化死亡率（SMR）。在排除观察的第一年之后，糖尿病患者中共发生了267例肾细胞癌（ICD - 7:180.0），而预期发生182.4例。在整个随访期间（1 - 25年），女性（SIR = 1.7，95%置信区间，CI = 1.4 - 2.0）和男性（SIR = 1.3；95% CI = 1.1 - 1.6）均观察到风险增加。肾癌（ICD - 7:180）死亡率风险更高（女性SMR = 1.9；95% CI = 1.7 - 2.2；男性SMR 1.7，95% CI = 1.4 - 1.9）。与普通人群相比，糖尿病患者患肾细胞癌的风险增加。
