Richards P A, Richards P D, Tiltman A J
Department of Anatomy, Faculty of Medicine, University of Pretoria, Republic of South Africa.
Hum Reprod Update. 1998 Sep-Oct;4(5):520-5. doi: 10.1093/humupd/4.5.520.
The aim of this study was to determine whether the ultrastructure of the non-neoplastic myometrial portion (host myometrium) of fibromyomatous uteri is normal or abnormal when compared to that of fibromyomata and normal myometria. Myometrial samples from 23 normal and 54 fibromyomatous uteri were examined at the ultrastructural level using standard electron microscopy techniques. Ultrastructural abnormalities of certain cellular organelles were noted in myocytes of fibromyomata but not in those of normal or host myometria. The sarcolemmal dense bands of host myometrial myocytes were of significantly greater length than those of normal myometria, but not significantly different to those of fibromyomata. Consequently, the numbers of caveolae in host myometria and fibromyomata are conceivably decreased in comparison to normal myometria. Host myometria can be, therefore, considered to be structurally abnormal. The specific structural abnormality noted may affect calcium metabolism in these tissues by causing a decrease in the cellular calcium extrusion mechanism and thus raising intracellular calcium concentrations. Such an abnormality may provide an answer, in terms of contraction abnormalities, for the unexplained infertility that occurs in a small percentage of symptomatic myomatous patients.
本研究的目的是确定与子宫肌瘤及正常子宫肌层相比，子宫肌瘤子宫的非肿瘤性子宫肌层部分（宿主子宫肌层）的超微结构是正常还是异常。使用标准电子显微镜技术在超微结构水平上检查了来自23个正常子宫和54个子宫肌瘤子宫的子宫肌层样本。在子宫肌瘤的肌细胞中发现了某些细胞器的超微结构异常，但在正常或宿主子宫肌层的肌细胞中未发现。宿主子宫肌层肌细胞的肌膜致密带长度明显长于正常子宫肌层，但与子宫肌瘤的无显著差异。因此，可以想象，与正常子宫肌层相比，宿主子宫肌层和子宫肌瘤中的小窝数量减少。因此，宿主子宫肌层可被认为在结构上是异常的。所观察到的特定结构异常可能通过导致细胞钙外排机制降低从而提高细胞内钙浓度来影响这些组织中的钙代谢。就收缩异常而言，这种异常可能为一小部分有症状的肌瘤患者出现的不明原因不孕提供一个答案。
