新型抗炎药苯恶洛芬合成中异构杂质的分析。
Analysis of isomeric impurities in a synthesis of the novel anti-inflammatory drug, benoxaprofen.
作者信息
Cockerill A F, Hall M, Mallen D B, Osborne D J, Prime D M
出版信息
J Chromatogr. 1976 Dec 22;129:339-45. doi: 10.1016/s0021-9673(00)87793-6.
PMID:1002793
Abstract
Gas-liquid chromatographic procedures are described for the determination of isomeric impurities in rho-chlorobenzoyl chloride and the intermediates, 2-(rho-nitrophenyl)-proprionitrile and 2-phenylpropionitrile, in a ten-stage synthesis of benoxaprofen, 2-(rho-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid.
摘要
本文描述了气相色谱法，用于测定在苯氧布洛芬（2-(对氯苯基)-α-甲基-5-苯并恶唑乙酸）十步合成过程中的对氯苯甲酰氯及其中间体2-(对硝基苯基)-丙腈和2-苯基丙腈中的异构杂质。
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Analysis of isomeric impurities in a synthesis of the novel anti-inflammatory drug, benoxaprofen.新型抗炎药苯恶洛芬合成中异构杂质的分析。
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