蝙蝠粪便作为一种室内过敏原。

Bat feces as an indoor allergen.

作者信息

Alonso A, Irañeta S G, Rodríguez S M, Scavini L M, Rodríguez S R

机构信息

Allergy Center, Hospital de Clínicas, Buenos Aires, Argentina.

出版信息

J Investig Allergol Clin Immunol. 1998 Nov-Dec;8(6):365-9.

PMID:10028484

Abstract

We have demonstrated in an animal model (specific IgG) as well as in atopic patients suffering from rhinitis/asthma (specific IgE) that bat feces have antigenic properties. A single peak with high glycoprotein content was obtained by chromatography, while SDS-PAGE revealed several proteins between 29 and 116 kDa which showed immune serum blotting at 43.6 and 66 kDa. Positive specific skin tests with bat feces and IgE-RAST anti-bat feces were detected in atopic patients living in tall buildings and old houses in Buenos Aires. As bat feces did not cross-react with bat epithelium, studies evaluating rat serum and epithelium and pigeon feces in order to analyze the role of bat serum proteins, such as IgA, are encouraged.

摘要

我们已经在动物模型（特异性IgG）以及患有鼻炎/哮喘的特应性患者（特异性IgE）中证实，蝙蝠粪便具有抗原特性。通过色谱法获得了一个高糖蛋白含量的单峰，而SDS-PAGE显示在29至116 kDa之间有几种蛋白质，在43.6和66 kDa处显示免疫血清印迹。在布宜诺斯艾利斯居住在高层建筑和老房子里的特应性患者中检测到了针对蝙蝠粪便的阳性特异性皮肤试验和抗蝙蝠粪便IgE-RAST。由于蝙蝠粪便与蝙蝠上皮细胞没有交叉反应，因此鼓励开展评估大鼠血清和上皮细胞以及鸽粪的研究，以分析蝙蝠血清蛋白（如IgA）的作用。