Propst T L, Lochmiller R L, Qualls C W, McBee K
Department of Zoology, Oklahoma State University, Stillwater 74078, USA.
Chemosphere. 1999 Feb;38(5):1049-67. doi: 10.1016/s0045-6535(98)00349-x.
Oil refineries inadvertently deposit a variety of complex mixtures of organic hydrocarbons and heavy metals in the soil, many of which are thought to be potent immunotoxicants. Terrestrial ecosystems such as this have not been adequately investigated with respect to wild rodent populations. The primary objective of this study was to use mesocosms to assess the immunotoxicity risks to feral small mammal populations associated with soils contaminated with petroleum refinery wastes. A series of 4-week and 8-week exposure trials using laboratory raised cotton rats (Sigmodon hispidus) were conducted in situ on three contaminated and three reference sites on the Oklahoma Refining Company Superfund Waste Site, Cyril, Oklahoma. Cotton rats exposed to these soils showed significant alterations in selected morphological traits, in vivo humoral immune responses, complement activity, and macrophage activity. However, immune alterations were not great, suggesting that resident small mammals may be a better biomonitoring choice than using mesocosms.
炼油厂会在土壤中无意沉积各种有机碳氢化合物和重金属的复杂混合物，其中许多被认为是强效免疫毒素。像这样的陆地生态系统，就野生啮齿动物种群而言，尚未得到充分研究。本研究的主要目的是利用中宇宙来评估与受石油炼制厂废物污染的土壤相关的野生小型哺乳动物种群的免疫毒性风险。在俄克拉荷马州西里尔市俄克拉荷马炼油公司超级基金废物处理场的三个污染场地和三个对照场地，使用实验室饲养的棉鼠（刚毛棉鼠）进行了一系列为期4周和8周的原位暴露试验。接触这些土壤的棉鼠在选定的形态特征、体内体液免疫反应、补体活性和巨噬细胞活性方面出现了显著变化。然而，免疫变化并不显著，这表明本地小型哺乳动物可能比使用中宇宙是更好的生物监测选择。
