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[初诊时伴有右心房肿瘤的恶性淋巴瘤化疗后发生病态窦房结综合征]

[Sick sinus syndrome after chemotherapy for malignant lymphoma with right atrial tumor at initial presentation].

作者信息

Miyata A, Fujiwara T, Fujii S, Kikuchi T, Osada T

机构信息

Department of Internal Medicine, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers.

出版信息

Rinsho Ketsueki. 1998 Dec;39(12):1190-3.

PMID:10028853
Abstract

A 56-year-old man was admitted complaining of throat discomfort and dyspnea. He was given a diagnosis of diffuse large B-cell lymphoma on the basis of findings from tumor biopsy specimens of his left pharynx. MRI tomograms and ultrasonic cardiograms revealed a right atrial tumor causing tricuspid stenosis. Although chemotherapy rendered the cardiac tumor indistinct on MRI and UCG images, gallium-67 scintigraphy still demonstrated abnormal cardiac uptake. After 6 courses of CHOP therapy, sick sinus syndrome with syncope suddenly developed in the patient. A cardiac pacemaker was immediately implanted, and radiotherapy was started. The patient's sinus rhythm returned to normal shortly afterward, and the gallium-67 uptake eventually disappeared. In this case gallium-67 scintigraphy was the only diagnostic procedure capable of detecting evidence of residual disease.

摘要

一名56岁男性因咽喉不适和呼吸困难入院。根据其左咽部肿瘤活检标本的检查结果,他被诊断为弥漫性大B细胞淋巴瘤。磁共振成像断层扫描和超声心动图显示右心房肿瘤导致三尖瓣狭窄。尽管化疗使心脏肿瘤在磁共振成像和超声心动图图像上不明显,但镓-67闪烁扫描仍显示心脏摄取异常。在接受6个疗程的CHOP治疗后,患者突然出现伴有晕厥的病态窦房结综合征。立即植入心脏起搏器,并开始放疗。此后不久,患者的窦性心律恢复正常,镓-67摄取最终消失。在这种情况下,镓-67闪烁扫描是唯一能够检测残留疾病证据的诊断方法。

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