Kitchen S G, Zack J A
Department of Medicine, UCLA School of Medicine and UCLA AIDS Institute, Los Angeles, California 90095, USA.
AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):143-8. doi: 10.1089/088922299311565.
HIV entry into a cell requires the coordinate cell surface expression of CD4 and one of several chemokine coreceptors. Here we have examined the expression of the two most widely utilized HIV coreceptors, CXCR4 and CCR5, on various lymphoid tissues derived from the fetus. CXCR4 and CCR5 are differentially expressed on lymphocytes in different lymphoid organs, which may reflect the maturational and functional status of cells within the organ. The different levels of coreceptor expression on CD4+ cells in the various organs may directly affect the targeting of CXCR4- and CCR5-tropic strains of HIV toward different fetal lymphoid tissues during in utero infection.
HIV进入细胞需要CD4和几种趋化因子共受体之一在细胞表面协同表达。在此，我们检测了两种最广泛使用的HIV共受体CXCR4和CCR5在源自胎儿的各种淋巴组织上的表达。CXCR4和CCR5在不同淋巴器官的淋巴细胞上差异表达，这可能反映了器官内细胞的成熟和功能状态。各器官中CD4+细胞上共受体表达水平的差异可能直接影响子宫内感染期间CXCR4嗜性和CCR5嗜性HIV毒株对不同胎儿淋巴组织的靶向作用。
