Andrade Z A, Guerret S, Fernandes A L
Centro de Pesquisas Gonçalo Moniz-Fiocruz, BA, Brasil.
Mem Inst Oswaldo Cruz. 1999 Jan-Feb;94(1):87-93. doi: 10.1590/s0074-02761999000100018.
Myofibroblasts, cells with intermediate features between smooth muscle cells and fibroblasts, have been described as an important cellular component of schistosomal portal fibrosis. The origin, distribution and fate of myofibroblasts were investigated by means of light, fluorescent, immunoenzymatic and ultrastructural techniques in wedge liver biopsies from 68 patients with the hepatosplenic form of schistosomiasis. Results demonstrated that the presence of myofibroblasts varied considerably from case to case and was always related to smooth muscle cell dispersion, which occurred around medium-sized damaged portal vein branches. By sequential observation of several cases, it was evident that myofibroblasts derived by differentiation of vascular smooth muscle and gradually tended to disappear, some of them further differentiating into fibroblasts. Thus, in schistosomal pipestem fibrosis myofibroblasts appear as transient cells, focally accumulated around damaged portal vein branches, and do not seem to have by themselves any important participation in the pathogenesis of hepatosplenic schistosomiasis.
肌成纤维细胞是一种具有平滑肌细胞和成纤维细胞中间特征的细胞，已被描述为血吸虫性门脉纤维化的重要细胞成分。通过光镜、荧光、免疫酶和超微结构技术，对68例肝脾型血吸虫病患者的楔形肝活检组织中肌成纤维细胞的起源、分布和转归进行了研究。结果表明，肌成纤维细胞的存在因病例而异，且总是与平滑肌细胞的分散有关，平滑肌细胞分散发生在中等大小的受损门静脉分支周围。通过对几例病例的连续观察，明显可见肌成纤维细胞由血管平滑肌分化而来，并逐渐趋于消失，其中一些进一步分化为成纤维细胞。因此，在血吸虫性干线型纤维化中，肌成纤维细胞表现为短暂存在的细胞，在受损门静脉分支周围局灶性聚集，似乎自身并未对肝脾型血吸虫病的发病机制产生重要影响。
