Borzone G, Ramírez B, Reyes T, Moreno R, Lisboa C, González S
Depto. Enfermedades Respiratorias, Pontificia Universidad Católica de Chile, Santiago, Chile.
Rev Med Chil. 1998 Oct;126(10):1153-60.
Although the hamster model of elastase induced emphysema is well characterized, the rat model has received less attention.
To evaluate the effect of a single intratracheal elastase dose on lung pathological changes of Sprague-Dawley rats.
Rats were injected with a single intratracheal elastase dose of 28 U/100 g body weight or saline and studied 7, 15, 30 and 365 days after injection.
Forty percent of rats died in the first 48 hours after injection, six were sacrificed at 7 days, 6 at 15 days, 7 at 30 days and 12 at 365 days. Progressive centroacinar emphysema was found from day 7 after elastase, with a persistent inflammatory reaction in the vicinity of emphysematous areas.
Present findings differ from the panacinar emphysema described in the hamster using a similar elastase dose.
尽管弹性蛋白酶诱导的肺气肿仓鼠模型已得到充分表征，但大鼠模型受到的关注较少。
评估气管内单次注射弹性蛋白酶剂量对Sprague-Dawley大鼠肺部病理变化的影响。
给大鼠气管内单次注射28 U/100 g体重的弹性蛋白酶或生理盐水，并在注射后7、15、30和365天进行研究。
40%的大鼠在注射后的前48小时死亡，6只在7天处死，6只在15天处死，7只在30天处死，12只在365天处死。弹性蛋白酶注射后第7天发现进行性中心腺泡型肺气肿，在肺气肿区域附近有持续的炎症反应。
目前的研究结果与使用相似弹性蛋白酶剂量在仓鼠中描述的全腺泡型肺气肿不同。
