一种用于产生严重单侧全腺泡肺气肿的犬模型。

A canine model for production of severe unilateral panacinar emphysema.

作者信息

Chino Kimiaki, Choong Cliff K, Toeniskoetter P Diane, Cooper Joel D, Lausberg Henning F, Bae Kyongtae T, Pierce John A, Hogg James C

机构信息

Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

出版信息

Exp Lung Res. 2004 Jun;30(4):319-32. doi: 10.1080/01902140490439022.

DOI:10.1080/01902140490439022

PMID:15204837

Abstract

The authors created a canine model of severe emphysema using whole lung lavage to deliver repeated porcine pancreatic elastase solution to the terminal airways and alveoli of the right lung. This model produces extreme unilateral panacinar emphysema closely resembling that encountered in patients with alpha1-antitrypsin deficiency. Because the contralateral lung remains functional, the animals can be maintained indefinitely. The model will be of value in developing imaging techniques capable of safely evaluating the effect of treatment on panacinar emphysema in alpha1-antitrypsin-deficient patients.

摘要

作者通过全肺灌洗向右肺的终末气道和肺泡反复输送猪胰弹性蛋白酶溶液，建立了重度肺气肿的犬模型。该模型产生的极度单侧全腺泡型肺气肿与α1抗胰蛋白酶缺乏症患者的肺气肿极为相似。由于对侧肺仍保持功能，这些动物可以无限期维持。该模型对于开发能够安全评估治疗对α1抗胰蛋白酶缺乏症患者全腺泡型肺气肿疗效的成像技术具有重要价值。