Ntanios F Y, MacDougall D E, Jones P J
School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, Ste-Anne-de-Bellevue, QC, Canada.
Can J Physiol Pharmacol. 1998 Jul-Aug;76(7-8):780-7. doi: 10.1139/cjpp-76-7-8-780.
To examine the effect of gender on the mechanisms of action of phytosterols extracted from tall oil (TO) and soybean (SB) on cholesterol and phytosterol metabolism, male and female hamsters were fed cholesterol-enriched diets containing 0.5 or 1% (w/w) TO or SB phytosterols for 90 days. Plasma lipoprotein cholesterol profile and tissue phytosterol and cholesterol biosynthesis levels were determined. Mean plasma total-cholesterol level in females fed 1% (w/w) SB was reduced (p<0.05) by 44%, while in males it was lowered (p<0.05) by 25% compared with their respective controls. Moreover, mean plasma total-cholesterol level was reduced (p<0.05) in male hamsters by -31% and female hamsters by -32% when fed 1% (w/w) TO. Cholesterol biosynthesis was higher (p<0.05) by twofold in groups fed TO at 0.5 and 1% (w/w) concentrations, compared with SB. Hamsters fed TO at 0.5 and 1% (w/w) levels also had higher (p<0.05) hepatic and enterocytic campesterol contents than SB-fed animals. These findings demonstrate gender differences in cholesterol metabolism in TO- and SB-fed hamsters. The results suggest that TO, conversely to SB phytosterol, is a more effective cholesterol-lowering agent in male, but not as much in female, hamsters, over a feeding period of 90 days.
为研究性别对从妥尔油（TO）和大豆（SB）中提取的植物甾醇在胆固醇和植物甾醇代谢作用机制上的影响，将雄性和雌性仓鼠喂食富含胆固醇的日粮，其中含有0.5%或1%（w/w）的TO或SB植物甾醇，持续90天。测定血浆脂蛋白胆固醇谱以及组织中植物甾醇和胆固醇的生物合成水平。与各自的对照组相比，喂食1%（w/w）SB的雌性仓鼠平均血浆总胆固醇水平降低了44%（p<0.05），而雄性仓鼠降低了25%（p<0.05）。此外，当喂食1%（w/w）TO时，雄性仓鼠的平均血浆总胆固醇水平降低了31%（p<0.05），雌性仓鼠降低了32%（p<0.05）。与SB组相比，喂食0.5%和1%（w/w）浓度TO的组胆固醇生物合成高出两倍（p<0.05）。喂食0.5%和1%（w/w）水平TO的仓鼠肝脏和肠细胞中的菜油甾醇含量也高于喂食SB的动物（p<0.05）。这些发现表明，在喂食TO和SB的仓鼠中，胆固醇代谢存在性别差异。结果表明，与SB植物甾醇相反，在90天的喂食期内，TO在雄性仓鼠中是一种更有效的降胆固醇剂，但在雌性仓鼠中效果不明显。
