Comparison of intraocular to plasma HIV-1 viral burden in patients with cytomegalovirus retinitis.
作者信息
Ciulla T A, Schnizlein-Bick C T, Danis R P, Frank M O, Wheat L J
机构信息
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis 46202, USA.
出版信息
Am J Ophthalmol. 1999 Feb;127(2):221-3. doi: 10.1016/s0002-9394(98)00345-6.
PURPOSE
To determine the relationship between plasma and intraocular human immunodeficiency virus-1 (HIV-1) viral loads in 12 consecutive patients undergoing ganciclovir implant surgery for cytomegalovirus (CMV) retinitis.
METHODS
Aqueous and vitreous specimens were assayed for HIV-1 viral load by polymerase chain reaction analysis (Roche Amplicor HIV Monitor; Roche Diagnostics Systems, Inc, Branchburg, New Jersey).
RESULTS
It was possible to quantitatively assay HIV-1 burden in intraocular fluids using polymerase chain reaction analysis. In general, patients with plasma viral loads less than 250,000 copies/ml had undetectable (<200 copies/ml) HIV-1 in their aqueous and vitreous.
CONCLUSIONS
It is likely that intraocular viral levels have several determinants in addition to plasma viral loads, with which they only partially correlate.
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