巨细胞病毒性视网膜炎患者眼内与血浆中HIV-1病毒载量的比较。
Comparison of intraocular to plasma HIV-1 viral burden in patients with cytomegalovirus retinitis.
作者信息
Ciulla T A, Schnizlein-Bick C T, Danis R P, Frank M O, Wheat L J
机构信息
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis 46202, USA.
出版信息
Am J Ophthalmol. 1999 Feb;127(2):221-3. doi: 10.1016/s0002-9394(98)00345-6.
PURPOSE
To determine the relationship between plasma and intraocular human immunodeficiency virus-1 (HIV-1) viral loads in 12 consecutive patients undergoing ganciclovir implant surgery for cytomegalovirus (CMV) retinitis.
METHODS
Aqueous and vitreous specimens were assayed for HIV-1 viral load by polymerase chain reaction analysis (Roche Amplicor HIV Monitor; Roche Diagnostics Systems, Inc, Branchburg, New Jersey).
RESULTS
It was possible to quantitatively assay HIV-1 burden in intraocular fluids using polymerase chain reaction analysis. In general, patients with plasma viral loads less than 250,000 copies/ml had undetectable (<200 copies/ml) HIV-1 in their aqueous and vitreous.
CONCLUSIONS
It is likely that intraocular viral levels have several determinants in addition to plasma viral loads, with which they only partially correlate.
目的
确定12例因巨细胞病毒（CMV）视网膜炎接受更昔洛韦植入手术的连续患者的血浆和眼内人类免疫缺陷病毒1型（HIV-1）病毒载量之间的关系。
方法
通过聚合酶链反应分析（罗氏Amplicor HIV监测仪；罗氏诊断系统公司，新泽西州布兰奇堡）检测房水和玻璃体标本中的HIV-1病毒载量。
结果
使用聚合酶链反应分析能够定量检测眼内液中的HIV-1负荷。一般来说，血浆病毒载量低于250,000拷贝/毫升的患者，其房水和玻璃体中的HIV-1检测不到（<200拷贝/毫升）。
结论
眼内病毒水平除了与血浆病毒载量有关外，可能还有几个决定因素，它们之间只是部分相关。
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