Thody A J, Cooper M F, Bowden P E, Meddis D, Shuster S
J Endocrinol. 1976 Dec;71(3):279-88. doi: 10.1677/joe.0.0710279.
The effects of alpha-MSH and testosterone propionate on sebum secretion, sebaceous gland volume, dermal lipogenesis, and preputial gland weight and lipogenesis were examined in hypophysectomized rats. Hypophysectomy reduced sebum secretion, sebaceous and preputial gland size, and dermal and preputial gland lipogenesis. The greatest effects were seen on the biosynthesis of wax esters and squalene. Testosterone propionate (TP) increased sebum secretion, sebaceous gland volume and preputial gland weight and lipogenic activity, but had no significant effect on the pattern of lipid labelling. alpha-MSH had no effect on sebaceous or preputial gland size, but increased sebum secretion and dermal lipogenesis, especially wax ester biosynthesis. When given together TP and alpha-MSH had a synergistic effect on sebum secretion and on dermal and preputial gland lipogenesis, and the pattern of lipid labelling was shifted towards normal. TP and alpha-MSH also showed synergism in increasing preputial gland weight, but together they had no greater effect on sebaceous gland volume than that achieved with TP alone. These results suggest that TP and alpha-MSH have different actions on the sebaceous glands with alpha-MSH acting predominantly on lipogenesis and TP on cellualr proliferation and turnover leading to an increase in gland size. Preputial glands differ from cutaneous sebaceous glands in their response to alpha-MSH and androgen which could be a reflection of their more specilized function.
在垂体切除的大鼠中研究了α-促黑素（alpha-MSH）和丙酸睾酮对皮脂分泌、皮脂腺体积、真皮脂肪生成以及包皮腺重量和脂肪生成的影响。垂体切除减少了皮脂分泌、皮脂腺和包皮腺大小以及真皮和包皮腺脂肪生成。对蜡酯和角鲨烯的生物合成影响最大。丙酸睾酮（TP）增加了皮脂分泌、皮脂腺体积、包皮腺重量和脂肪生成活性，但对脂质标记模式没有显著影响。α-促黑素对皮脂腺或包皮腺大小没有影响，但增加了皮脂分泌和真皮脂肪生成，尤其是蜡酯生物合成。当一起给予时，TP和α-促黑素对皮脂分泌以及真皮和包皮腺脂肪生成具有协同作用，并且脂质标记模式向正常转变。TP和α-促黑素在增加包皮腺重量方面也显示出协同作用，但它们一起对皮脂腺体积的影响并不比单独使用TP时更大。这些结果表明，TP和α-促黑素对皮脂腺有不同作用，α-促黑素主要作用于脂肪生成，而TP作用于细胞增殖和更新，导致腺体大小增加。包皮腺对α-促黑素和雄激素的反应与皮肤皮脂腺不同，这可能反映了它们更特殊的功能。
