Makrantonaki Evgenia, Ganceviciene Ruta, Zouboulis Christos
Departments of Dermatology, Venereology, Allergology and Immunology; Dessau Medical Center; Dessau, Germany.
Dermatoendocrinol. 2011 Jan;3(1):41-9. doi: 10.4161/derm.3.1.13900.
The pathogenesis of acne, a disease of the pilosebaceous follicle and one of the most common chronic skin disorders, is attributed to multiple factors such as increased sebum production, alteration of the quality of sebum lipids, inflammatory processes, dysregulation of the hormone microenvironment, interaction with neuropeptides, follicular hyperkeratinisation and the proliferation of Propionibacterium acnes within the follicle. In particular, the sebaceous gland plays an exquisite role in the initiation of the disease as it possesses all the enzyme machinery for the production of hormones and cytokines. In addition, in response to the altered tissue environment in the pilosebaceous follicle as well as in answer to emotional fret, stress response system mechanisms with induction of central and local expression of neuropeptides, are also initiated. This review summarises the latest advances in understanding the role of sebaceous gland cells in the pathomechanism of acne.
痤疮是一种毛囊皮脂腺疾病，也是最常见的慢性皮肤疾病之一，其发病机制归因于多种因素，如皮脂分泌增加、皮脂脂质质量改变、炎症过程、激素微环境失调、与神经肽的相互作用、毛囊过度角化以及痤疮丙酸杆菌在毛囊内的增殖。特别是皮脂腺在疾病的起始阶段起着至关重要的作用，因为它拥有合成激素和细胞因子的所有酶机制。此外，针对毛囊皮脂腺中改变的组织环境以及情绪烦躁，应激反应系统机制会启动，诱导神经肽在中枢和局部的表达。这篇综述总结了在理解皮脂腺细胞在痤疮发病机制中的作用方面的最新进展。
