促黑激素研究35年的进展
Thirty-five years of progress in the study of MSH.
作者信息
Shizume K
出版信息
Yale J Biol Med. 1985 Nov-Dec;58(6):561-70.
Abstract
In this paper, initial work on MSH at Dr. Lerner's laboratory in Portland, Oregon, from 1952 to 1954 is presented. The development of an in vitro bioassay method enabled us to show increased urinary excretion of MSH in Addison's disease. The ability of MSH to increase skin pigmentation in man was also demonstrated. Subsequent work on MSH during the past thirty years is reviewed, such as characterization of alpha- and beta-MSH and their precursors in the pituitary gland and localization of MSH-like peptides in various regions of the brain. Finally there are presented the characterization of gamma-MSH, the hypothermic effect of intracisternal administration of gamma-MSH, the effect of corticortropin releasing factor on increased secretion of alpha-MSH from rat pituitary, and the effect of arginine vasopressin on secretion of alpha-MSH from pituitary adenoma.
摘要
本文介绍了1952年至1954年在俄勒冈州波特兰市勒纳博士实验室开展的有关促黑素（MSH）的初步研究工作。一种体外生物测定方法的开发使我们能够证明艾迪生病患者尿中促黑素排泄增加。促黑素增加人体皮肤色素沉着的能力也得到了证实。文中还回顾了过去三十年里有关促黑素的后续研究工作，比如垂体中α-促黑素和β-促黑素及其前体的特性鉴定，以及脑不同区域中促黑素样肽的定位。最后介绍了γ-促黑素的特性、脑池内注射γ-促黑素的降温作用、促肾上腺皮质激素释放因子对大鼠垂体α-促黑素分泌增加的影响，以及精氨酸加压素对垂体腺瘤α-促黑素分泌的影响。
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本文引用的文献
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Biochemistry of melanin formation.黑色素形成的生物化学
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