Metzer E, Agmon V, Andoren N, Cohen D
Department of Molecular Virology, The Faculty of Medicine, Hebrew University of Jerusalem.
Epidemiol Infect. 1998 Dec;121(3):555-9. doi: 10.1017/s0950268898001526.
The relative frequency of salmonella strains isolated from hospitalized and non-hospitalized patients in Southern Israel changed during the period, 1994-6. Salmonella enterica serotype Typhimurium definitive phage-type 104 (DT104) appeared in Israel in 1994 and became the most prevalent strain in 1996. An outbreak of enteritis due to Salmonella enterica serotype Agona occurred in Israel, in October 1994 and lasted for 4 months. The relative frequency of Salmonella enterica serotype Enteritidis remained almost constant during these years, with seasonal fluctuations only. The importance of the increase in the prevalence of Typhimurium DT104 has been the epidemic spread of a multiresistant strain of R-type ACT (A, ampicillin; C, chloramphenicol; T, tetracycline) belonging to this phage-type. Since 1995 the frequency of Typhimurium DT104 isolates that possess, in addition to the above R-type, a chromosomally encoded resistance to the quinolone drug, nalidixic acid, increased tenfold. In 1996, 27% of the Typhimurium DT104 isolates were of R-type ACTN. S. Enteritidis exhibited over 95% susceptibility to at least eight of the most commonly used antibiotic drugs, and none of the isolates was resistant to quinolone or fluoroquinoline.
1994 - 1996年期间，从以色列南部住院和非住院患者中分离出的沙门氏菌菌株的相对频率发生了变化。肠炎沙门氏菌鼠伤寒亚种定型噬菌体104型（DT104）于1994年出现在以色列，并于1996年成为最普遍的菌株。1994年10月，以色列发生了由肠炎沙门氏菌阿贡纳血清型引起的肠炎疫情，持续了4个月。这些年里，肠炎沙门氏菌肠炎血清型的相对频率几乎保持不变，仅存在季节性波动。鼠伤寒DT104患病率增加的重要性在于，属于该噬菌体类型的R型ACT（A，氨苄青霉素；C，氯霉素；T，四环素）多耐药菌株的流行传播。自1995年以来，除上述R型外，还对喹诺酮类药物萘啶酸具有染色体编码抗性的鼠伤寒DT104分离株的频率增加了10倍。1996年，27%的鼠伤寒DT104分离株为R型ACTN。肠炎沙门氏菌对至少八种最常用的抗生素药物的敏感性超过95%，且没有分离株对喹诺酮或氟喹诺酮耐药。
