P菌毛和其他黏附素可增强大肠杆菌在婴儿早期肠道中的存留能力。
P fimbriae and other adhesins enhance intestinal persistence of Escherichia coli in early infancy.
作者信息
Adlerberth I, Svanborg C, Carlsson B, Mellander L, Hanson L A, Jalil F, Khalil K, Wold A E
机构信息
Department of Clinical Immunology, Göteborg University, Sweden.
出版信息
Epidemiol Infect. 1998 Dec;121(3):599-608. doi: 10.1017/s0950268898001137.
Resident and transient Escherichia coli strains were identified in the rectal flora of 22 Pakistani infants followed from birth to 6 months of age. All strains were tested for O-antigen expression, adhesin specificity (P fimbriae, other mannose-resistant adhesins or type 1 fimbriae) and adherence to the colonic cell line HT-29. Resident strains displayed higher mannose-resistant adherence to HT-29 cells, and expressed P fimbriae (P = 0.0036) as well as other mannose-resistant adhesins (P = 0.012) more often than transient strains. In strains acquired during the first month of life, P fimbriae were 12 times more frequent in resident than in transient strains (P = 0.0006). The O-antigen distribution did not differ between resident and transient strains, and none of the resident P-fimbriated strains belonged to previously recognized uropathogenic clones. The results suggest that adhesins mediating adherence to intestinal epithelial cells, especially P fimbriae, enhance the persistence of E. coli in the large intestine of infants.
在22名从出生到6个月大的巴基斯坦婴儿的直肠菌群中鉴定出了常驻和短暂存在的大肠杆菌菌株。对所有菌株进行了O抗原表达、黏附素特异性（P菌毛、其他抗甘露糖黏附素或1型菌毛）以及对结肠细胞系HT-29的黏附测试。常驻菌株对HT-29细胞表现出更高的抗甘露糖黏附性，并且比短暂菌株更频繁地表达P菌毛（P = 0.0036）以及其他抗甘露糖黏附素（P = 0.012）。在出生后第一个月获得的菌株中，常驻菌株中P菌毛的出现频率比短暂菌株高12倍（P = 0.0006）。常驻和短暂菌株之间的O抗原分布没有差异，并且所有常驻的P菌毛化菌株都不属于先前公认的尿路致病性克隆。结果表明，介导对肠道上皮细胞黏附的黏附素，尤其是P菌毛，增强了大肠杆菌在婴儿大肠中的持久性。
Zotero 插件