Protection by Rhinax in various models of ulceration in rats.

The effect of Rhinax on gastric damage in different animal models including gastric ulceration induced by a necrotic agent such as 0.6 N HCl, indomethacin, and intragastric distension was studied. Treatment with Rhinax at a dose of 160 mg/kg protected gastric mucosa against the damage induced by oral administration of indomethacin and intragastric distension. The volume and acidity of gastric juice in pyloric ligated rats was reduced by Rhinax. It also significantly promoted gastric mucus secretion in normal animals. On the basis of these observations, we conclude that Rhinax possesses anti-ulcer activity and that the observed activity may be due to the modulation of defensive factors by improvement in gastric cytoprotection.