School of Pharmaceutical Sciences, Shobhit University, NH-58, Modipuram, Meerut 250110, UP, India.
J Ethnopharmacol. 2011 Mar 24;134(2):294-7. doi: 10.1016/j.jep.2010.12.019. Epub 2010 Dec 21.
Cedrus deodara (Roxb.) Loud. is used in Ayurvedic medicine to treat peptic ulcer.
To evaluate the gastric antisecretory and antiulcer activity of Cedrus deodara.
The volatile oil extracted by steam distillation of Cedrus deodara wood was examined for its gastric antisecretory and antiulcer effect in the pylorus-ligated rat model and ethanol induced gastric lesions in rats.
The volatile oil showed significant antisecretory activity as evidenced by decreased gastric fluid volume, total acidity, free acidity and increase in the pH of the gastric fluid in pylorus-ligated rats. Our studies also revealed that pretreatment with Cedrus deodara significantly reduced the number of ulcer, ulcer score and ulcer index in pylorus-ligated and ethanol treated rats. The antiulcer activity of Cedrus deodara is further supported by histopathological study which showed protection of mucosal layer from ulceration and inflammation.
The present findings conclude that volatile oil of Cedrus deodara wood has potent antisecretory and antiulcer effects and justify the traditional usage of this herb to treat peptic ulcers.
雪松（Roxb.）Loud. 在印度阿育吠陀医学中用于治疗消化性溃疡。
评估雪松的胃分泌抑制和抗溃疡活性。
通过水蒸气蒸馏法从雪松木材中提取挥发油，在幽门结扎大鼠模型中检查其对胃分泌的抑制作用和对大鼠乙醇诱导的胃损伤的作用。
挥发油表现出显著的分泌抑制活性，表现为胃液体体积减少、总酸度、游离酸度降低，胃液 pH 值升高。我们的研究还表明，雪松预处理可显著减少幽门结扎和乙醇处理大鼠的溃疡数、溃疡评分和溃疡指数。雪松的抗溃疡活性还得到组织病理学研究的支持，该研究显示粘膜层免受溃疡和炎症的保护。
本研究结果表明，雪松木材的挥发油具有强大的分泌抑制和抗溃疡作用，证明了这种草药在治疗消化性溃疡方面的传统用途。
