Nunes P H M, Cavalcanti P M S, Galvão S M P, Martins M C C
Departamento de Biofísica e Fisiologia/CCS, Universidade Federal do Piauí, Campus Universitário Ministro Petrônio Portela Bloco SG 8, Ininga, 64049-550, Teresina-PI, Brazil.
Pharmazie. 2009 Jan;64(1):58-62.
This study investigates the effects of an ethanolic extract from the stem bark of Combretum leprosum Mart. & Eiche (Combretaceae) on experimental ulcers induced by ethanol and indomethacin and on gastric secretion and mucus content in pylorus-ligated rats. The effects were compared with those of ranitidine and carbenoxolone. Combretum leprosum orally administered elicited a complete inhibition of the appearance of gastric lesions induced by ethanol and a partial reduction when indomethacin was used as an ulcerogenic agent. Moreover, the protection against gastric ulceration induced by ethanol was decreased with indomethacin pretreatment. The intraduodenal administration of Combretum leprosum in four-hour pylorus-ligated rats increased the volume and pH of gastric juice while decreasing the acid output and produced a significant increase in gastric wall mucus content. The major compounds detected in a preliminary phytochemical screening were triterpenes, flavonoids, taninns and saponins. This study provides evidence that the ethanolic extract of Combretum leprosum possesses gastroprotective and anti-ulcerogenic effects, which are related to the inhibition of the gastric acid secretion and an increase of mucosal defensive factors such as mucus and prostaglandin.
本研究考察了麻风风车子（使君子科）茎皮乙醇提取物对乙醇和吲哚美辛诱导的实验性溃疡以及幽门结扎大鼠胃液分泌和黏液含量的影响。并将其与雷尼替丁和甘珀酸的作用进行了比较。口服麻风风车子可完全抑制乙醇诱导的胃部病变的出现，而当使用吲哚美辛作为致溃疡剂时则可部分减轻病变。此外，吲哚美辛预处理会降低对乙醇诱导的胃溃疡的保护作用。在幽门结扎4小时的大鼠中十二指肠内给予麻风风车子可增加胃液的体积和pH值，同时降低酸分泌，并使胃壁黏液含量显著增加。初步植物化学筛选检测到的主要化合物为三萜类、黄酮类、鞣质和皂苷。本研究提供了证据表明麻风风车子乙醇提取物具有胃保护和抗溃疡作用，这与抑制胃酸分泌以及增加黏液和前列腺素等黏膜防御因子有关。
