Bizjak E D, Haug M T, Schilz R J, Sarodia B D, Dresing J M
College of Pharmacy, University of Arizona, USA.
Pharmacotherapy. 1999 Feb;19(2):245-8. doi: 10.1592/phco.19.3.245.30930.
Intravenous azithromycin is increasingly administered for treatment of hospitalized patients with community-acquired pneumonia. Macrolide antibiotics cause ototoxicity, which occurs most frequently when high serum concentrations are achieved. Current dosing guidelines for intravenous azithromycin can result in much higher serum concentrations than is seen with oral administration. We describe a 47-year-old woman who developed complete deafness after receiving 8 days of intravenous azithromycin.
静脉注射阿奇霉素越来越多地用于治疗社区获得性肺炎的住院患者。大环内酯类抗生素会导致耳毒性，在血清浓度较高时最常发生。目前静脉注射阿奇霉素的给药指南可能导致血清浓度比口服给药时高得多。我们描述了一名47岁女性，在接受8天静脉注射阿奇霉素后出现完全性耳聋。
