Ress B D, Gross E M
Division of Head and Neck Surgery, University of California-San Diego, USA.
Ann Otol Rhinol Laryngol. 2000 Apr;109(4):435-7. doi: 10.1177/000348940010900416.
Azithromycin, an azalide antibiotic, rarely causes ototoxicity. According to the few reports in existence, azithromycin-induced ototoxicity occurred following prolonged high-dose therapy in patients with acquired immunodeficiency syndrome and resulted in a reversible sensorineural hearing loss. We present a case of irreversible sensorineural hearing loss due to azithromycin ototoxicity in an otherwise healthy woman following low-dose exposure to azithromycin.
阿奇霉素是一种氮杂内酯类抗生素，很少引起耳毒性。根据现有的少数报告，阿奇霉素引起的耳毒性发生在获得性免疫缺陷综合征患者长期高剂量治疗之后，并导致可逆性感音神经性听力损失。我们报告一例原本健康的女性在低剂量接触阿奇霉素后因阿奇霉素耳毒性导致不可逆性感音神经性听力损失的病例。
