未经治疗的帕金森病中神经和心理状态与多巴胺的相关性。
Dopamine correlates of neurological and psychological status in untreated Parkinsonism.
作者信息
Hoehn M M, Crowley T J, Rutledge C O
出版信息
J Neurol Neurosurg Psychiatry. 1976 Oct;39(10):941-51. doi: 10.1136/jnnp.39.10.941.
Abstract
Thirty-seven untreated Parkinsonism patients showed significant positive correlations among decreased excretion of free dopamine, MMPI scores indicative of schizophrenic-like looseness of thinking, and the severity of all Parkinsonism signs except tremor. The data could indicate that abnormalities of dopamine metabolism may underlie both the motor and mental abnormalities of Parkinsonism.
摘要
37名未经治疗的帕金森病患者的游离多巴胺排泄减少、明尼苏达多项人格测验（MMPI）中提示精神分裂症样思维松弛的得分以及除震颤外所有帕金森病体征的严重程度之间存在显著正相关。这些数据可能表明多巴胺代谢异常可能是帕金森病运动和精神异常的基础。
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