Selikhova M V, Kogan B M, Serkin G V, Gusev E I
Zh Nevrol Psikhiatr Im S S Korsakova. 2002;102(9):37-40.
Catecholamine metabolism was evaluated by daily urine excretion in patients with Parkinson's disease of tremor (18 patients) and rigid (14 patients) types. The group included 16 untreated patients. According to urine analysis, most informative peripheral markers for dopamine metabolism proved to be DOPA excretion, 3,4-dioxyphenylacidic acid (DOPAA) level and DOPA/DOPAA ratio. In the initial disease stage, a marked decrease of free dopamine and noradrenaline as well as dopamine metabolism intensification with corresponding DOPA/DOPAA ratio decrease were found. Significantly lower DOPAA and DOPA excretion was detected in patients with predominance of akinesia and rigidity types compared to tremor ones. In contrast to untreated patients, those treated with drugs containing dopamine revealed correlations between daily urine DOPA excretion as well as DOPA/DOPAA ratio with neurological symptoms severity.
通过每日尿排泄评估震颤型（18例）和强直型（14例）帕金森病患者的儿茶酚胺代谢。该组包括16例未经治疗的患者。根据尿液分析，多巴胺代谢最具信息性的外周标志物被证明是多巴排泄、3,4-二羟基苯乙酸（DOPAA）水平和多巴/ DOPAA比值。在疾病初始阶段，发现游离多巴胺和去甲肾上腺素显著减少，以及多巴胺代谢增强，相应的多巴/ DOPAA比值降低。与震颤型患者相比，运动不能和强直型占优势的患者中检测到的DOPAA和多巴排泄显著更低。与未经治疗的患者相比，用含多巴胺药物治疗的患者每日尿多巴排泄以及多巴/ DOPAA比值与神经症状严重程度之间存在相关性。
