给予苯妥英钠后豚鼠急性传导速度的变化
Acute conduction velocity changes in guinea-pigs after administration of diphenylhydantoin.
作者信息
Le Quesne P M, Goldberg V, Vajda F
出版信息
J Neurol Neurosurg Psychiatry. 1976 Oct;39(10):995-1000. doi: 10.1136/jnnp.39.10.995.
Abstract
Motor nerve conduction velocity was measured after dosing guinea-pigs with 200-400 μmol/kg diphenylhydantoin (DPH) daily for three to four days. Conduction velocity fell by a mean value of 13% in animals that achieved plasma DPH levels over 200 μmol/l. There was no change in velocity with DPH levels below this value.
摘要
在豚鼠每日给予200 - 400μmol/kg苯妥英（DPH），持续三到四天后，测量其运动神经传导速度。在血浆DPH水平超过200μmol/l的动物中，传导速度平均下降了13%。当DPH水平低于此值时，速度没有变化。
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