Mavroudakis N, Brunko E, Nogueira M C, Zegers de Beyl D
Laboratoire de Neurophysiologie Clinique, Hôpital Erasme, Brussels, Belgium.
Electroencephalogr Clin Neurophysiol. 1991 Mar;78(3):263-6. doi: 10.1016/0013-4694(91)90042-3.
We studied the acute effects of an intravenous loading dose of DPH (16 mg/kg body weight) on peripheral and central somatosensory conduction in 10 normal volunteers. Somatosensory evoked potentials were recorded before and at regular intervals after DPH infusion. There was no effect on peripheral conduction. DPH significantly delayed N13 peak latency without changing conduction in the posterior spinal columns. Although the N13-N20 interpeak interval remained stable because of the parallel shift of the 2 peaks, the central conduction time measured from onset latencies of N11 and N20 significantly increased. We conclude that acute administration of DPH at serum levels below 30 micrograms/ml induces a reversible delay of synaptic transmission in spinal and central somatosensory structures.
我们研究了静脉注射负荷剂量的苯妥英（DPH，16毫克/千克体重）对10名正常志愿者外周和中枢躯体感觉传导的急性影响。在注射DPH之前和之后定期记录体感诱发电位。对外周传导没有影响。DPH显著延迟了N13峰潜伏期，而不改变后脊髓柱的传导。尽管由于两个峰的平行移动，N13-N20峰间间隔保持稳定，但从N11和N20起始潜伏期测量的中枢传导时间显著增加。我们得出结论，血清水平低于30微克/毫升时急性给予DPH会导致脊髓和中枢躯体感觉结构中突触传递的可逆延迟。
