智障癫痫患者的脑电图与苯妥英钠毒性
Electroencephalography and phenytoin toxicity in mentally retarded epileptic patients.
作者信息
Iivanainen M, Viukari M, Seppäläinen A M, Helle E P
出版信息
J Neurol Neurosurg Psychiatry. 1978 Mar;41(3):272-7. doi: 10.1136/jnnp.41.3.272.
Abstract
There were significantly more diffuse and focal electroencephalographic abnormalities in 127 mentally retarded epileptic patients treated with phenytoin than in 68 epileptics without phenytoin. Phenytoin intoxication made the difference still more pronounced. Monitoring drug levels and electroencephalograms appears to be the method of choice for ensuring safe and effective medication in intractable epilepsy.
摘要
在接受苯妥英治疗的127例智障癫痫患者中，弥漫性和局灶性脑电图异常明显多于68例未使用苯妥英的癫痫患者。苯妥英中毒使这种差异更加明显。监测药物水平和脑电图似乎是确保难治性癫痫患者安全有效用药的首选方法。
相似文献
1
Electroencephalography and phenytoin toxicity in mentally retarded epileptic patients.智障癫痫患者的脑电图与苯妥英钠毒性
J Neurol Neurosurg Psychiatry. 1978 Mar;41(3):272-7. doi: 10.1136/jnnp.41.3.272.
2
Cerebellar atrophy in phenytoin-treated mentally retarded epileptics.
Epilepsia. 1977 Sep;18(3):375-86. doi: 10.1111/j.1528-1157.1977.tb04980.x.
3
Diphenylhydantoin as an anticonvulsant: evaluation of treatment in forty mentally subnormal epileptics.
J Ment Defic Res. 1969 Sep;13(3):212-8. doi: 10.1111/j.1365-2788.1969.tb01084.x.
4
Involuntary movements caused by phenytoin intoxication in epileptic patients.癫痫患者苯妥英中毒所致的不自主运动。
J Neurol Neurosurg Psychiatry. 1975 Mar;38(3):225-31. doi: 10.1136/jnnp.38.3.225.
5
Effect of diphenylhydantoin therapy on folate metabolism of mentally retarded epileptics.苯妥英治疗对智障癫痫患者叶酸代谢的影响。
Tohoku J Exp Med. 1973 May;110(1):59-68. doi: 10.1620/tjem.110.59.
6
Chronic diphenyl hydantoin encephalopathy in mentally retarded children and adolescent with severe epilepsy.患有严重癫痫的智障儿童和青少年中的慢性苯妥英脑病。
Acta Neurol Scand. 1979 Jul;60(1):50-5. doi: 10.1111/j.1600-0404.1979.tb02950.x.
7
Folate metabolism and problem behaviour in mentally handicapped epileptics.
J Ment Defic Res. 1987 Jun;31 ( Pt 2):163-8. doi: 10.1111/j.1365-2788.1987.tb01352.x.
8
9
Salivary phenytoin levels in institutionalized epileptics.
J Chronic Dis. 1983;36(12):899-906. doi: 10.1016/0021-9681(83)90012-7.
10
Diphenylhydantoin as an anticonvulsant: protein binding and fluctuation of the serum and cerebrospinal fluid levels in forty mentally subnormal epileptics.
J Ment Defic Res. 1969 Dec;13(4):235-44. doi: 10.1111/j.1365-2788.1969.tb01087.x.
引用本文的文献
1
Clinical and experimental studies of phenytoin-induced hyperkinesias.
J Neural Transm. 1979;45(4):291-305. doi: 10.1007/BF01247146.
本文引用的文献
1
DIPHENYLHYDANTOIN ACTIVATED SEIZURES.二苯妥英钠诱发的癫痫发作。
Neurology. 1965 Aug;15:716-22. doi: 10.1212/wnl.15.8.719.
2
SERUM PHENYTOIN DETERMINATIONS IN EPILEPTICS.
Epilepsia. 1964 Dec;5:364-70. doi: 10.1111/j.1528-1157.1964.tb03342.x.
3
Clinical and electroencephalographic correlations with serum levels of diphenylhydanotin.临床及脑电图与血清苯妥英水平的相关性
Arch Neurol. 1960 Jun;2:624-30. doi: 10.1001/archneur.1960.03840120030004.
4
Dilantin toxicity. A clinical and electroence-phalographic study.
Neurology. 1961 Oct;11:912-21. doi: 10.1212/wnl.11.10.912.
5
Effect of drugs on discharge characteristics of chronic epileptogenic lesions.
Neurology. 1959 Jul;9(7):492-8. doi: 10.1212/wnl.9.7.492.
6
Electroencephalogram in anticonvulsant-induced folate deficiency.
Br Med J. 1971 Apr 24;2(5755):207. doi: 10.1136/bmj.2.5755.207.
7
Pseudodegenerative disease due to diphenylhydantoin intoxication.
Arch Neurol. 1969 Dec;21(6):631-7. doi: 10.1001/archneur.1969.00480180087008.
8
Studies on the metabolism of phenytoin.
Epilepsia. 1966 Sep;7(3):238-45. doi: 10.1111/j.1528-1157.1966.tb03802.x.
9
[Correlation between brain electric activity and overdose of anticonvulsants].[脑电活动与抗惊厥药物过量之间的相关性]
Nervenarzt. 1972 May;43(5):270-2.
10
EEG and human psychopharmacology.
Annu Rev Pharmacol. 1969;9:241-58. doi: 10.1146/annurev.pa.09.040169.001325.
Zotero 插件