McCracken R O, Taylor D D
Science. 1980 Mar 14;207(4436):1220-2. doi: 10.1126/science.7355285.
Mebendazole was highly effective against the helminth parasite Trichinella spiralis in mice subjected to a 3-day course of treatment during the invasive and encystment phases of experimental trichinellosis. When treatment began either 2 or 4 weeks after the mice were inoculated with parasites, the number of larvae developing in the host musculature was greatly reduced by twice-daily oral administration of 3.125, 6.25, or 12.5 milligrams of mebendazole per kilogram of body weight.
在实验性旋毛虫病的侵入期和包囊期，对小鼠进行为期3天的治疗过程中，甲苯咪唑对蠕虫寄生虫旋毛虫具有高效性。当在小鼠接种寄生虫后2周或4周开始治疗时，通过每日两次口服每千克体重3.125、6.25或12.5毫克甲苯咪唑，宿主肌肉组织中发育的幼虫数量大大减少。
