Grandjean C J
J Natl Cancer Inst. 1976 Jul;57(1):181-5. doi: 10.1093/jnci/57.1.181.
The metabolism of [2-14C]N-nitrosohexamethyleneimine in male MRC-Wistar rats was studied and some of the major urinary metabolites were identified. The extent of total oxidation to 14CO2 was 18.1% in 24 hours and radioactivity incorporation was observed in various tissues; that in the liver was the highest. Analysis of urine after 24 hours showed that 36.7% of the radioactivity administered was excreted by this route, with a minimum of 11 products present. Hexamethyleneimine (HX), epsilon-caprolactam, epsilon-aminocaproic acid, and 6-aminocaprohydroxamic acid were the identified metabolites. Of the remaining products, two appeared to result from HX metabolism and one was a glucuronide conjugate. No parent compound was found.
对雄性MRC-威斯塔大鼠体内[2-¹⁴C]N-亚硝基六亚甲基亚胺的代谢进行了研究，并鉴定了一些主要的尿液代谢产物。24小时内氧化为¹⁴CO₂的总量为18.1%，并且在各个组织中观察到放射性掺入；肝脏中的掺入量最高。24小时后的尿液分析表明，经此途径排出了给药放射性的36.7%，至少存在11种产物。已鉴定出的代谢产物有六亚甲基亚胺（HX）、ε-己内酰胺、ε-氨基己酸和6-氨基己酰异羟肟酸。其余产物中，两种似乎是HX代谢产生的，一种是葡糖醛酸缀合物。未发现母体化合物。
