亚硝胺的体内代谢IV. 给予1-亚硝基吡咯烷后从大鼠尿液中分离出3-羟基-1-亚硝基吡咯烷
Metabolism of nitrosamines in vivo IV. Isolation of 3-hydroxy-1-nitrosopyrrolidine from rat urine after application of 1-nitrosopyrrolidine.
作者信息
Krüger F W, Bertram B
出版信息
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975;83(3):255-60. doi: 10.1007/BF00304096.
PMID:125015
Abstract
After i. p. application of 6 mg/30 muCi/kg 2,5- and 3,4--14C-nitrosopyrrolidine about 20% of the radioactivity is exhaled as 14-CO2 and about 7% is found in the urine. One of the urinary metabolites was identified by thin layer chromatography, combined GC/MS spectrometry and ultraviolet absorption as 3-hydroxy-1-nitrosopyrrolidine.
摘要
经腹腔注射给予6毫克/30微居里/千克的2,5-和3,4-14C-亚硝基吡咯烷后，约20%的放射性以14CO2的形式呼出，约7%出现在尿液中。通过薄层色谱、气相色谱/质谱联用和紫外吸收法鉴定出一种尿液代谢产物为3-羟基-1-亚硝基吡咯烷。
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